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Kristina Hedfalk

Forskare
Biokemi

Tel: 031-786 3923
E-post: kristina.hedfalk@chem.gu.se
Besöksadress: Lundbergslaboratoriet, Medicinaregatan 9 C, rum 1208

Forskning

Min forskning riktar sig mot membranbundna proteiners struktur, funktion och reglering med ett särskilt fokus på aquaporiner; vattenkanalar i cellmembranet hos allt levande. Ett stort intresse finns också för att uppnå en ökad kunskap om produktionen av membranbundna proteiner i syfte att minimera den välkända ’flaskhalsen’ för detaljstudier av eukaryota membranproteiner i synnerhet.

Undervisning

Jag undervisar i biokemi, både grund- och avancerade nivå, på följande kurser:

  • Grundläggande kemi (KEM021)
  • Biokemi 1 (KEM060)
  • Genteknisk proteinmodellering (KEM300)

Uppdrag

  • Styrelsen för den tidigare institutionen för kemi, företrädare för lärare
  • Ansvarar för kursen KEM300 (Genteknisk proteinmodellering)
  • Ordförande för Innovationsrådet.

 

Publikationer

2013

  • Kristina Hedfalk (2013).
    Further advances in the production of membrane proteins in Pichia pastoris. 2165-5987, GUP 177812

  • Kristina Hedfalk; Fredrik Öberg (2013).
    Recombinant production of the human aquaporins in the yeast Pichia pastoris (Invited Review). 0968-7688, GUP 169525

  • Jakob Mutanu Jungersted; Julie Bomholt; Niada Bajraktari; Jesper Søndergaard Hansen; Dan A Klærke; Per Amstrup Pedersen; Kristina Hedfalk; Kent Høier Nielsen; Tove Agner; Claus Hélix-Nielsen (2013).
    In vivo studies of aquaporins 3 and 10 in human stratum corneum. 1432-069X, GUP 177811

2012

  • Kristina Hedfalk (2012).
    Codon optimisation for heterologous gene expression in yeast. , GUP 169556

  • F. Itel; S. Al-Samir; Fredrik Öberg; M. Chami; M. Kumar; C. T. Supuran; P. M. T. Deen; W. Meier; Kristina Hedfalk; G. Gros; V. Endeward (2012).
    CO2 permeability of cell membranes is regulated by membrane cholesterol and protein gas channels 0892-6638, GUP 168819

2011

  • Fredrik Öberg; Jennie Sjöhamn; Gerhard Fischer; Anders Pedersen; Richard Neutze; Kristina Hedfalk (2011).
    Glycosylation increases the thermostability of human aquaporin 10 protein. 1083-351X, GUP 148038

  • Fredrik Öberg; Jennie Sjöhamn; Matthew T Conner; Roslyn M. Bill; Kristina Hedfalk (2011).
    Improving recombinant eukaryotic membrane protein yields in Pichia pastoris: the importance of codon optimization and clone selection. 1464-5203, GUP 149188

2010

  • Cecilia Ferndahl; N. Bonander; C. Logez; R. Wagner; Lena Gustafsson; Christer Larsson; Kristina Hedfalk; R. A. J. Darby; R. M. Bill (2010).
    Increasing cell biomass in Saccharomyces cerevisiae increases recombinant protein yield: the use of a respiratory strain as a microbial cell factory 1475-2859, GUP 124350

  • Susanna Törnroth-Horsefield; Kristina Hedfalk; Gerhard Fischer; Karin Lindkvist-Petersson; Richard Neutze (2010).
    Structural insights into eukaryotic aquaporin regulation. 1873-3468, GUP 124245

2009

  • Gerhard Fischer; Urszula Kosinska-Eriksson; Camilo Aponte-Santamaría; Madelene Palmgren; Cecilia Geijer; Kristina Hedfalk; Stefan Hohmann; Bert L de Groot; Richard Neutze; Karin Lindkvist-Petersson (2009).
    Crystal structure of a yeast aquaporin at 1.15 angstrom reveals a novel gating mechanism. 1545-7885, GUP 100482

  • Maria Nyblom; Anna Frick; Yi Wang; Mikael Ekvall; Karin Hallgren; Kristina Hedfalk; Richard Neutze; Emad Tajkhorshid; Susanna Törnroth-Horsefield (2009).
    Structural and functional analysis of SoPIP2;1 mutants adds insight into plant aquaporin gating. 1089-8638, GUP 100498

  • Fredrik Öberg; Mikael Ekvall; Maria Nyblom; Anna Backmark; Richard Neutze; Kristina Hedfalk (2009).
    Insight into factors directing high production of eukaryotic membrane proteins; production of 13 human AQPs in Pichia pastoris. 1464-5203, GUP 100488

2008

  • Anna Backmark; Maria Nyblom; Susanna Törnroth-Horsefield; Urszula Kosinska-Eriksson; Kristina Hedfalk; Karin Lindkvist-Petersson; Richard Neutze; Rob Horsefield (2008).
    Affinity tags can reduce merohedral twinning of membrane protein crystals , GUP 78414

  • Kristina Hedfalk; Nina Pettersson; Fredrik Oberg; Stefan Hohmann; Euan Gordon (2008).
    Production, characterization and crystallization of the Plasmodium falciparum aquaporin. 1096-0279, GUP 75035

2007

  • A Fantoni; RM Bill; Lena Gustafsson; Kristina Hedfalk (2007).
    Improved yields of full-length functional human FGF1 can be achieved using the methylotrophic yeast Pichia pastoris , GUP 26365

  • Maria Nyblom; Fredrik Öberg; Karin Lindkvist-Petersson; Karin Hallgren; H. Findlay; J. Wikstrom; A. Karlsson; Örjan Hansson; P. J. Booth; Roslyn M. Bill; Richard Neutze; Kristina Hedfalk (2007).
    Exceptional overproduction of a functional human membrane protein 1046-5928, GUP 80912

  • Susanna Törnroth-Horsefield; Kristina Hedfalk; M. Karlsson; U. Johanson; Y. Wang; E. Tajkhorshid; Rob Horsefield; M. Nyblom; A. Backmark; P. Kjellbom; Richard Neutze (2007).
    Aquaporin gating , GUP 61212

2006

  • AR Aricescu; R Assenberg; RM Bill; D Busso; VT Chang; SJ Davis; A Dubrovsky; Lena Gustafsson; Kristina Hedfalk; et al et al. (2006).
    Eukaryotic expression: developments for structural proteomics , GUP 26364

  • Kristina Hedfalk; Susanna Törnroth-Horsefield; Maria Nyblom; U Johanson; P Kjellbom; Richard Neutze (2006).
    Aquaporin gating , GUP 26374

  • Susanna Törnroth-Horsefield; Y Wang; Kristina Hedfalk; U Johanson; M Karlsson; E Tajkhorshid; Richard Neutze; P Kjellbom (2006).
    Structural mechanism of plant aquaporin gating 0028-0836, GUP 26382

2005

  • Nicklas Bonander; Kristina Hedfalk; Christer Larsson; Petter Mostad; Cecilia Chang; Lena Gustafsson; Roslyn Bill (2005).
    Design of improved membrane protein production experiments: Quantitation of the host response , GUP 9946

  • Caroline Filipsson; Kristina Hedfalk; Sara Karlgren; J. G. Mullins; Roslyn M. Bill; Stefan Hohmann; Jan Rydström (2005).
    Role of Fps1 hydrophilic extensions and identification of residues controlling glycerol transport 1742-464X, GUP 64688

  • Cecilia Henricsson; Maria de Jesus-Ferreira; Kristina Hedfalk; Karin Elbing; Christer Larsson; Joakim Norbeck; Roslyn Bill; Stefan Hohmann; Lena Gustafsson (2005).
    Engineering of a novel Saccharomyces cerevisiae wine strain with a respiratory phenotype at high external glucose concentrations 0099-2240, GUP 9951

2004

  • Caroline Filipsson; Kristina Hedfalk; Sara Karlgren; J. G. L Mullins; Roslyn M. Bill; Stefan Hohmann; Jan Rydström (2004).
    Role of Fps1 hydrophilic extensions and identification of residues controlling glycerol transport , GUP 56435

  • Kristina Hedfalk; Roslyn M. Bill; Johathan G.L. Mullins; Sara Karlgren; Caroline Filipsson; Johanna Bergström; Markus J. Tamás; Jan Rydström; Stefan Hohmann (2004).
    A Regulatory Domain in the C-terminal Extension of the Yeast Glycerol Channel Fps1p , GUP 35160

  • Susanna Törnroth; M Karlsson; Kristina Hedfalk; P Kjellbom; Richard Neutze (2004).
    Structural studies on PM28A, an aquaporin from spinach 0005-2728, GUP 26386

2003

  • Markus J. Tamás; Sara Karlgren; Roslyn M. Bill; Kristina Hedfalk; L Allegri; Marie Ferreira; J.M. Thevelein; Jan Rydström; J. G. L Mullins; Stefan Hohmann (2003).
    A Short Regulatory Domain Restricts Glycerol Transport through Yeast Fps1p , GUP 69071

2002

  • Kristina Hedfalk (2002).
    Structure, Function and Regulation of Fps1p. A Eukaryotic Solute Efflux Channel , GUP 375

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