Within the Biophysics research constellation, protein NMR researchers are well known for developing new methodology for proteins requiring spectra of very high dimensionality and/or fast acquisition.
Typical applications might be structural studies of natively unfolded proteins or proteins of limited stability. Spectra with four or more dimensions are recorded using novel sampling techniques ("projection spectroscopy") and analysed with adapted data decomposition algorithms ("multi-way decomposition").
The biophysics cluster also applies EPR spectroscopy to study biological systems. This technique is used to probe molecules with unpaired electrons such as transition-metal-containing proteins and organic radicals. Electron-transfer reactions in photosynthesis and water-transport studies of aquaporins are also studied using spectroscopic tools.
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