Biochemistry

Membrane proteins govern energy transduction, control cellular ion and metabolite concentrations, interpret the cellular environment and initiate responses to external stimuli. A high-resolution structure of a membrane protein provides unique insight into how it performs remarkable chemical processes within the cell.

Membrane protein structural biology has had major impact within the life sciences, recognised by Noble Prizes in Chemistry in 1988, 1997 and 2003. Membrane proteins also encompass the largest families of pharmaceutical targets, representing a multi-billion euro industry with tremendously positive influence on human health. Membrane proteins are dramatically underrepresented structurally (approximately 1.5 % of unique structures in the protein data bank correspond to membrane proteins) and there is an even greater paucity of structural information regarding how they change conformation during their functional cycles.

More information about the research

• Membrane protein & kinetic crystallography